Many strains of fungi have been utilized by the food industry and have been chosen for his or her ability to ferment, produce flavor or produce heterologous molecules. Two fungi used to provide food products have potential probiotic effects on intestinal inflammation, in keeping with a brand new study. The research, published in a journal of the American Society for Microbiology, reveals a possible latest option to develop latest probiotics.
“There is much to be learned by studying the role of fungal strains in the microbiota and host health, and also that species used only in food processing may be a source of new probiotics,” study lead writer Matthias L. Richard, P. HD said. D., Joie-Ann Josas, Research Director at INRAE ​​on the Maccles Institute in France.
To date, little is understood concerning the diversity of foodborne yeasts and their potential impact on the gut microbiota and intestinal health. Yeasts are microscopic fungi? Consists of solitary cells that reproduce by budding. Some have been used for tons of of years, reminiscent of for making wine and bread, or for making or ripening many other cheese crusts, e.g.
The researchers conducted the brand new study as they work to learn more concerning the potential effects of fungal microbiota on human health. In this particular study, the thought was to specifically goal fungi that food firms use to make food products (cheese, charcuterie). “Since our interest is more focused on the role of fungi in gut health and the development of inflammatory bowel diseases (Crohn's disease and ulcerative colitis), we monitored the effect of these fungi on in vitro and in vivo models,” Richard said. .
The researchers first chosen yeasts that were widely utilized in food production and represented a big selection of various yeast species after which tested them either in easy interaction tests with cultured human cells. or in a particular animal model that mimics ulcerative colitis.
They found that in a set of strains used for food production, some strains can exert a useful effect on the gut and the host within the context of inflammation. They identified 2 yeast strains, which have potential useful effects on inflammatory settings in a mouse model of ulcerative colitis. Several additional experiments were conducted in an try and understand the mechanisms behind these effects. In the case of , the protection appears to be driven by a change within the bacterial microbiota after administration to mice, leading to a change in susceptibility to intestinal inflammation through an unknown mechanism.
“These 2 strains have never been specifically described with such a beneficial effect, so even if it does it needs to be studied further, and specifically to see How they work in humans is a promising discovery,” Richard said.
And the strain has potential as a probiotic yeast strain to fight inflammation within the gut, but more studies are needed to grasp the mechanisms by which these strains act on gut health.