July 19, 2023 – Researchers studying a weight loss program to enhance brain health were surprised by the outcomes of a recent experiment, because the brain health of subjects on the MIND weight loss program was no higher after three years than that of subjects on a control weight loss program.
About half of the 604 participants followed the Mediterranean–DASH Intervention for Neurodegenerative Delay weight loss program for 3 years. The other half underwent only mild calorie restriction.
“In cognitively unimpaired participants with a family history of dementia, changes in cognitive abilities and brain MRI results … did not differ significantly between those who followed the MIND diet and those who followed the control diet,” the study authors wrote.
The MIND weight loss program improved the brains of those that followed it for 3 years. Magnetic resonance imaging scans showed fewer small lesions and more gray and white matter, the cognitive center of the brain and the “communication highway,” respectively. CNN reported.
But the brains of participants who didn't follow the MIND weight loss program showed similar improvements.
“We really expected the MIND diet to be more effective than the control group, so we were quite surprised by the result,” said lead writer Lisa Barnes, deputy director of the Alzheimer's Disease Research Center at Rush University Medical Center in Chicago.
The study was published in New England Journal of Medicine.
The MIND weight loss program includes many elements of the Mediterranean weight loss program, a weight loss program that favors fish, fruits, vegetables, whole grains, beans, and olive oil. The MIND weight loss program also includes a part of the Dietary Approaches to Stop Hypertension (DASH) weight loss program, which goals to enhance blood pressure and reduce the danger of heart attacks, strokes, and a few conditions that may result in dementia.
CNN reported concerns concerning the latest study.
“My biggest concern with this study from the beginning was that three years might be too short a time to have an impact on a disease course that develops over many decades,” said Dr. Walter Willett, professor of epidemiology and nutrition on the Harvard TH Chan School of Public Health and professor of drugs at Harvard Medical School.
Willett referred to a older clinical study The study found that eating more beta-carotenoids – the antioxidants present in red, yellow, orange and dark green fruit and veggies – provided cognitive advantages – but only after years of following the weight loss program.
Barnes said previous research has shown that following the MIND weight loss program and the Mediterranean weight loss program provides significant protection against cognitive decline and Alzheimer's disease, but those studies lasted significantly longer than the brand new three-year study.