In the United States, essentially the most well -known parasitic insect within the skin, called Nimatud, is a hook worm. But globally, it's estimated that greater than 600 million individuals are affected by the skin entering the skin, which can also be known. This species is usually present in tropical and subtractical areas with poor sanitation infrastructure. Surmuts within the prescriptions of an affected host are emitted, after which enter the bottom to attend for a brand new host. When they affect a brand new host, they may cause serious illnesses.
Currently, the infection is treated with ivermectin, but some semodoxes are beginning to create resistance to this primary line. New drugs are needed, and UCLA neuro biologists can have just found a touch to affect their design.
In an article published, UCLA researchers have reported that thread worms respond otherwise to carbon dioxide at various stages of their life cycle. They also identified a few neurons and a gene that detects a partner2 In these parasites, and find out how to further research find out how to manipulate them. Because the co –2 There is plenty of tissues corresponding to lungs and intestines, which may also help scientists find CO by targeting CO and finding infections.2-The sensing path.
“Skin -penetrating Nematud is a high contest2 “Our results show that carbon dioxide plays a vital role because of the reactions of carbon dioxide, because they play a vital role in the life of the micro -biology, immunology and molecular genetics, and the UCLA professor,” said and UCLA professor of Elsa Helium.
The thread insect infection begins when the larvae is emitted within the host pope. The infective larvae is then crawl into the pope and the soil to seek out a bunch to see. After finding a bunch and entering the host via skin, the half -traveled the host's body and is believed to go through the lungs. They eventually move to the small intestine, where they live as parasitic adults and lay eggs. The larvae who saves these eggs are excluded, and the bicycle resumes.
UCLA researchers found that Infective Larva is repulsed by a partner2While nanfective larvae and adults have a neutral response. The young men who migrate contained in the body are drawn to the partner2.
“Co –2 Infective larvae can launch a passenger host search, where the partner is, where a partner2 The level is high, “said Nonel Banerjee, a post documentary researcher and the first author of the study at the helium lab.” And partner.2 Already attractive within the worm contained in the body can attract them to the lungs and intestines, that are high within the partner2“
Helium, Banerjee and colleagues discovered these reactions by exposing the thread insects at various stages of life cycle.2 And studying their behavior. He then identified the neurons who detect the partner2 And promote the response to the associated behavior. They found that they express a receptor called Neuron GCY-9, known for helping the Nimadids senses.2. By removing the GCY-9 gene, the thread insects were unable to detect the partner2Showing that it's mandatory for the conduct's response with the gene partner2.
Identification of the chemosisi mechanism that creates an interaction between the parasites and their human hosts may also help scientists design latest medicines that concentrate on the partner.2-The sensing path. For example, drugs that prevent the GCY-9 function.2Which can prevent an infection from establishing or reducing the severity of the present infection. Additional genes in the longer term study will likely be identified2-The sensing route that may act as molecular goals for brand new anti -parasatic medicines.
This research was provided by the National Institutes of Health.